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Karl Barry Sharpless
Chemist

Karl Barry Sharpless

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Developing selective chemical reactions and click chemistry, earning two chemistry Nobel Prizes.

Asymmetric epoxidation · Click chemistry

Born
28 April 1941
Birthplace
Philadelphia, United States

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Karl Barry Sharpless

K. Barry Sharpless is an American chemist whose methods help researchers build molecules more reliably.

Early life

Early interests

Spent childhood summers fishing in New Jersey.

Chemistry training

Studied at Dartmouth and completed a Stanford doctorate in 1968.

Career

  1. 1970

    MIT appointment

    Started his independent academic career.

  2. 1990

    Scripps move

    Joined the California research institute.

  3. 2022

    Second Nobel

    Shared the chemistry prize after his first award in 2001.

Contributions

Asymmetric epoxidation

Developed a method for controlling molecular handedness.

Click chemistry

Proposed efficient reactions for joining molecular building blocks.

Copper-catalysed coupling

Developed a key click reaction independently of Morten Meldal.

Beyond the lab

Laboratory safety

Losing sight in one eye in a lab accident made him an advocate for protective glasses.

Life outside chemistry

Has maintained a lifelong interest in fishing.

Sources & photo creditBiography and careerFurther sourceIdentity and date cross-check

Photo: Cmichel67. CC BY-SA 4.0 · Original image. Cropped and displayed in monochrome.