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Discover›Medicine
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Peter J. Ratcliffe
Physician

Peter J. Ratcliffe

Famoose for

Discovering how cells sense oxygen availability

Oxygen sensing · Erythropoietin

Born
14 May 1954
Birthplace
Morecambe

More people

Florence NightingaleHelping establish modern professional nursing.Alexander FlemingDiscovering penicillin’s antibacterial effect.Edward JennerDeveloping smallpox vaccination using material from cowpox.

Peter J. Ratcliffe

Peter Ratcliffe brought questions from kidney medicine into molecular biology. His research helped reveal how cells detect oxygen levels and change gene activity in response.

Early life

Medical training

Studied at Cambridge and St Bartholomew’s before specialising in renal medicine at Oxford.

Career

  1. 1989

    Oxford laboratory

    Established a group investigating erythropoietin regulation.

  2. 2016

    Crick Institute

    Became clinical research director.

  3. 2019

    Nobel Prize

    Shared the medicine prize with William Kaelin Jr. and Gregg Semenza.

Contributions

Oxygen sensing

Investigated mechanisms linking oxygen availability to cellular responses.

Erythropoietin

Studied regulation of the hormone that stimulates red blood-cell production.

Beyond work

Family

Married Fiona Mary MacDougall in 1983.

Sources & photo creditBiography and career ↗Biographical references ↗Additional biographical or achievement source ↗

Original photograph. Cropped and displayed in monochrome.

Photo: Secretaría de Ciencia, Tecnología e Innovación Productiva.. CC BY 2.5 ar · Original image. Cropped and displayed in monochrome.